2+ hour ago  (834+ words) Weekly subcutaneous obexelimab significantly prolongs time to disease flare, increases remission rates and reduces glucocorticoid requirements compared with placebo in patients with active immunoglobulin G4-related disease (Ig G4-RD), a new trial has shown. Ig G4-RD is a chronic, systemic fibroinflammatory…...

3+ day, 8+ hour ago  (589+ words) Repeated antibiotic exposure in early childhood may disrupt the developing gut microbiome and increase the risk of later inflammatory bowel disease (IBD), with the strongest association observed for Crohn's disease, according to a recent study. The incidence of childhood-onset IBD…...

2+ week, 5+ day ago  (628+ words) Hospital Healthcare Europe - Do Not Process My Personal Information With persistently poor survival and restricted treatment options for pleural mesothelioma, a UK-first trial aims to determine whether highly targeted proton beam therapy can improve survival and quality of life in…...

2+ week, 6+ day ago  (744+ words) A new UK clinical trial, known as SPOT-IT, is investigating whether existing treatments for pre-cancerous skin lesions could help prevent squamous cell carcinoma in people at particularly high risk due to being immunocompromised, as this horizon horizon-scanning feature explains. Squamous…...

1+ mon, 2+ day ago  (235+ words) While frailty is more common in women with acute MI, its association with mortality and adverse outcomes appears stronger in men, study finds....

1+ mon, 5+ hour ago  (501+ words) Published in the journal JAMA Network Open, the study aimed to clarify whether invasive management provides clinical benefit in frail older patients with NSTEMI " a population historically under-represented in randomised cardiovascular trials despite experiencing high rates of adverse outcomes. A…...

1+ mon, 1+ day ago  (545+ words) A five-year, "3m research programme, led by King's College London, aims to tackle one of the most persistent and under-recognised challenges in inflammatory arthritis: chronic pain. Inflammatory arthritis encompasses a range of autoimmune conditions, including rheumatoid arthritis, psoriatic arthritis and axial…...

1+ mon, 4+ day ago  (469+ words) Most systemic psoriasis treatments carry similar risks of serious infection, long-term registry data suggest, although risankizumab is associated with a lower risk than some comparators in recurrent-event analyses. Systemic therapies for psoriasis alter immune function and may increase susceptibility to…...

1+ mon, 1+ week ago  (430+ words) The use of a funnel-shaped intra-abdominal mesh during permanent colostomy formation after rectal cancer surgery significantly reduces parastomal hernia rates over three years without increasing complications, according to long-term randomised trial data. Parastomal hernia is one of the most common…...

1+ mon, 1+ week ago  (932+ words) SMMILe, a new artificial intelligence algorithm developed by Dr Zeyu Gao at the University of Cambridge, can analyse complex cancer images and map tumours with greater spatial accuracy, offering more reliable visual cues for pathologists and opening the door for…...